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Enamel matrix derivative : ウィキペディア英語版 | Enamel matrix derivative In dentistry, enamel matrix derivative (EMD) is an extract of porcine fetal tooth material used to biomimetically stimulate the soft and hard tissues surrounding teeth to regrow (in a process known as regeneration) following tissue destruction. ==Discovery of EMP's role in cementogenesis== There are three hard tissues that comprise human teeth: enamel, dentin and cementum. The majority of the tooth structure is formed from dentin, and the enamel serves as the superficial layer of the crown while the cementum serves to cover the root. In the mid-1990s, however, it was discovered that a very thin layer of enamel actually exists between the dentin and cementum on the roots of adult human teeth. This led researchers to conclude that enamel matrix proteins (or EMPs) laid down by Hertwig's epithelial root sheath serve as precursors to acellular cementum during its formation, known as cementogenesis.〔Hammarström, L. Enamel matrix, cementum development and regeneration. ''J Clin Perio'' 1997;24:658-68.〕 The presence of acellular cementum acts to signal the development of periodontal ligament fibers, followed by new alveolar bone, thus leading to the formation of the tissues of the periodontium.〔Beertsen W,''et al.'' The periodontal ligament: A unique, multifunctional, connective tissue. ''Perio 2000'' 1997;13:20-40.〕
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